The study by Ordóñez-Mena et al12 enrolled cohort data from European population-based cohort studies, whereas the previous studies enrolled nested case-control studies conducted in the United States with different adjustments for confounders. Art. Declaration of conflicting interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Another meta-analysis of 8 studies did not show any significant association between Fok1, Bsm1, Taq1, Apa1, VDR polymorphism, and breast cancer risk (Table 2).45 The VDR polymorphism case-control studies (Table 2) showed different associations between different VDR polymorphisms and breast cancer risk among different populations: ApaI and TaqI confer high breast cancer susceptibility among Egyptian women,46 Taq1 among Jordanian women,47 Bsma1 among Pakistani women,48 and poly(A) microsatellite among Iranian women.25 BsmI but not Fok1 was associated with the risk of breast cancer among Iranian women.49 However, Shaikh et al50 in their mini review compare the impact of VDR gene polymorphisms, Fok1, Bsm1, Taq1, Apa1, and poly(A), on the development of breast cancer and showed inconsistent results, with no conclusive statements about the significance of the VDR genotype on breast carcinoma development (Table 2). Indian J Pediatr. Recently, extensive research on its extraskeletal actions has linked vitamin D deficiency to an increased risk of infection, diabetes mellitus types 1 and 2, cardiovascular disease, obesity, asthma, inflammatory bowel disease, colon, breast, prostate and ovarian cancer and some neurological diseases. Please read and accept the terms and conditions and check the box to generate a sharing link. The half-life of 1,25(OH)2D is only 4 to 6 hours and 1000-fold less than the total 25(OH)D. So, serum vitamin D is usually determined by measuring 25(OH)D biomarker that has a half-life of about 2 to 3 weeks.1, Different medical societies’ guidelines have different definitions for the cutoff values of vitamin D level. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website. So a recent study by Grant and Boucher23 developed a model for use in designing and analyzing vitamin D RCTs with application to cancer incidence. For breast cancer–controlled studies, case-control studies consistently find an inverse correlation between 25(OH)D and breast cancer risk.15,16 Bilinski et al15 showed that 25(OH)D concentration below 75 nmol/L at diagnosis was associated with a significantly higher risk of breast cancer. Serum Total 25-Hydroxyvitamin D Levels in Patients With Cutaneous Malignant Melanoma: A Case-Control Study in a Low-Risk Southern European Population. The D3 form is produced from 7-dihydroxycholesterol under the skin that is exposed to UV-B light (cholecalciferol) and D2 form originates from dietary sources such as plants and fish (ergocalciferol). They also found that dietary intake of vitamin D was inversely associated with breast cancer risk (OR fourth quartile versus first quartile = 0.39; 95% CI = 0.196-0.784), and this inverse association remained significant after adjusting for the confounding factors.18 Similar results were reported by Shaukat et al19 who studied 42 newly diagnosed breast cancer cases and 52 controls. Association between 25-hydroxyvitamin D concentration and breast cancer risk in an Australian population: an observational case-control study, Serum 25-hydroxyvitamin D deficiency and increased risk of breast cancer among Korean women: a case-control study, 25-Hydroxyvitamin D and breast cancer, colorectal cancer, and colorectal adenomas: case-control versus nested case-control studies, Vitamin D status and risk of breast cancer in Iranian women: a case-control study, Association between vitamin D deficiency and breast cancer, Calcium and vitamin D supplements and health outcomes: a reanalysis of the Women’s Health Initiative (WHI) limited-access data set, The influence of health and lifestyle characteristics on the relation of serum 25-hydroxyvitamin D with risk of colorectal and breast cancer in postmenopausal women, Serum 25-hydroxyvitamin D concentrations ≥40 ng/ml are associated with >65% lower cancer risk: pooled analysis of randomized trial and prospective cohort study, Randomized controlled trials of vitamin D and cancer incidence: a modeling study, Effect of vitamin D and calcium supplementation on cancer incidence in older women: a randomized clinical trial, Vitamin D receptor poly(A) microsatellite polymorphism and 25-hydroxyvitamin D serum levels: association with susceptibility to breast cancer, Premenopausal plasma 25-hydroxyvitamin D, mammographic density, and risk of breast cancer, Vitamin D-related gene polymorphisms, plasma 25-hydroxyvitamin D, and breast cancer risk, Plasma 25-hydroxyvitamin D3 is associated with decreased risk of postmenopausal breast cancer in whites: a nested case-control study in the multiethnic cohort study, Role of vitamin D deficiency and lack of sun exposure in the incidence of premenopausal breast cancer: a case control study in Sabzevar, Iran, Serum vitamin D, risk of breast cancer within five years, Vitamin D status at breast cancer diagnosis: correlation with tumor characteristics, disease outcome, and genetic determinants of vitamin D insufficiency, Vitamin D deficiency in newly diagnosed breast cancer patients, Serum 25-hydroxyvitamin D levels in early and advanced breast cancer, A survey on the relationship between serum 25-hydroxy vitamin D level and tumor characteristics in patients with breast cancer, Association of serum level of vitamin D at diagnosis with breast cancer survival: a case-cohort analysis in the pathways study, Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women, Vitamin D deficiency is correlated with poor outcomes in patients with luminal-type breast cancer, Vitamin-D status at breast cancer diagnosis: correlation with social and environmental factors and dietary intake, Vitamin-D receptors in breast-cancer cells, Genomic vitamin D signaling in breast cancer: insights from animal models and human cells, Sunlight, polymorphisms of vitamin D-related genes and risk of breast cancer, Variants of the VDR gene and risk of colon cancer (United States), Functional significance of vitamin D receptor FokI polymorphism in human breast cancer cells, Association of the vitamin D receptor FokI gene polymorphism with sex- and non-sex-associated cancers: a meta-analysis, Vitamin D receptor polymorphism and breast cancer risk: a meta-analysis, Association of vitamin D receptor gene polymorphisms with breast cancer risk in an Egyptian population, Association between serum 25-hydroxy vitamin D concentration and TaqI vitamin D receptor gene polymorphism among Jordanian females with breast cancer, Association between the Bsml polymorphism in the vitamin D receptor gene and breast cancer risk: results from a Pakistani case-control study, Vitamin D receptor gene polymorphism: association with susceptibility to early-onset breast cancer in Iranian, BRCA1/2-mutation carrier and non-carrier patients.

Amd Ryzen Laptops Uk, Lock Doh (remix), Things To Do In Christchurch For Couples, Chic Clothing, Sting Wwe Return,